EGF816 mesylate
CAS No. 1508250-72-3
EGF816 mesylate ( EGF-816 mesylate;Nazartinib mesylate )
Catalog No. M12106 CAS No. 1508250-72-3
EGF816 (Nazartinib) is a potent, irreversible, mutant-selective EGFR inhibitor with Ki and Kinact of 31 nM and 0.222 min-1, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 873 | Get Quote |
|
50MG | 1782 | Get Quote |
|
100MG | 2250 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameEGF816 mesylate
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NoteResearch use only, not for human use.
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Brief DescriptionEGF816 (Nazartinib) is a potent, irreversible, mutant-selective EGFR inhibitor with Ki and Kinact of 31 nM and 0.222 min-1, respectively.
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DescriptionEGF816 (Nazartinib) is a potent, irreversible, mutant-selective EGFR inhibitor with Ki and Kinact of 31 nM and 0.222 min-1, respectively; shows potent inhibition of pEGFR levels in H3255, HCC827, and H1975 with EC50 of 5, 1, and 3 nM, which harbor the L858R, Ex19del, and L858R/T790M mutations, respectively, inhibitscell proliferation with EC50 of 9, 11, and 25 nM, but not the WT EGFR-containing patient-derived cell lines; potently inhibits the most common EGFR mutations L858R, Ex19del, and T790M in vitro; causes tumor regressions in vivo in several patient-derived xenograft models, also demonstrates antitumor activity in exon 20 insertion mutant model.Lung Cancer Phase 3 Clinical
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SynonymsEGF-816 mesylate;Nazartinib mesylate
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR
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Research AreaCancer
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IndicationLung Cancer
Chemical Information
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CAS Number1508250-72-3
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Formula Weight591.12
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Molecular FormulaC27H35ClN6O5S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC1=NC=CC(=C1)C(=O)NC2=NC3=C(N2C4CCCCN(C4)C(=O)C=CCN(C)C)C(=CC=C3)Cl.CS(=O)(=O)O
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Chemical Name4-Pyridinecarboxamide, N-[7-chloro-1-[(3R)-1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]hexahydro-1H-azepin-3-yl]-1H-benzimidazol-2-yl]-2-methyl-, methanesulfonate (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lelais G, et al. J Med Chem. 2016 Jul 28;59(14):6671-89.
2. Jia Y, et al. Cancer Res. 2016 Mar 15;76(6):1591-602.
3. Liao BC, et al. Lung Cancer. 2017 Aug;110:7-13.
2. Jia Y, et al. Cancer Res. 2016 Mar 15;76(6):1591-602.
3. Liao BC, et al. Lung Cancer. 2017 Aug;110:7-13.
molnova catalog
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